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KMID : 0363620150360020021
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Journal of Korean Oriental Medicine
2015 Volume.36 No. 2 p.21 ~ p.35
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Effect of Picrorrhizae Rhizoma Aqueous Extracts on Paw Chronic Inflammation In Mice
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Leem Ji-Young
Ku Sae-Kwang
Seo Bu-Il
Jeon Mi-Hye
Park Ji-Ha
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Abstract
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Objectives: The purpose of this study was to examine the efficacy of Picrorrhizae Rhizoma (PR) aqueous extracts on the formalin-induced paw chronic inflammation in mice.
Methods: PR extracts (500, 250 and 125mg/kg) or distilled water (DW) were orally administered once a day for 10 days to formalin-injected chronic inflammatory mice. The paw thicknesses and volumes were measured daily and the paw wet-weight and histological profiles were conducted at termination with paw tumor necrosis factor (TNF)-α contents measurement. The anti-inflammatory effects of PR extracts were compared with dexamethasone.
Results: In DW treated control group, the paw thickness, paw wet-weights and paw TNF-α contents were markedly
increased. Severe chronic inflammation signs such as severe fibrosis, the formation of necrotic debris, and infiltration of inflammatory cells were detected in histopathological observations. However, these formalin-induced changes were dramatically decreased by treatment of dexamethasone and all three different dosages of PR extracts. The anti-inflammatory effects of PR at highest dose were slighter than that of dexamethasone, but it did not show any harmful effects on the body weight contrary to dexamethasone.
Conclusion: These results suggest that PR extracts have safe and favorable effects on formalin-induced chronic inflammation.
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KEYWORD
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Chronic inflammation, Picrorrhizae Rhizoma, Dexamethasone, tumor necrosis factor (TNF)-α
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